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Predisposition to cancer in the Bonaparte family

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Cited by (45)

  • Gastric cancer genetic predisposition and clinical presentations: Established heritable causes and potential candidate genes

    2022, European Journal of Medical Genetics
    Citation Excerpt :

    We will further review published data on candidate genes tested for their potential role in heritable GC, and provide a rationale for the identification of particularly relevant candidate genes in this disease. Evidence for familial predisposition to GC dates back historically to the 18th Century, was observed in the Bonaparte Family and described by Sokoloff in 1938 (Sokoloff, 1938). It took 60 years for a direct association between a germline heritable genetic defect and increased risk to diffuse gastric cancer (DGC) development to be discovered (Guilford et al., 1998).

  • A Review of the Genomics of Gastric Cancer

    2006, Clinical Gastroenterology and Hepatology
  • Is there a link between environmental factors and a genetic predisposition to cancer? A lesson from a familial cluster of gastric cancers

    2003, European Journal of Cancer
    Citation Excerpt :

    Familial clustering of GC has long been recognised. The most famous FGC pedigree is that of the Bonaparte family: the Emperor, two sisters, one brother, the father and, probably, a paternal aunt died from stomach cancer [18]. Predictive genetic testing is an essential step for the clinical management of affected families.

  • Genetic epidemiologic aspects of gastric cancer in Iceland

    2002, Journal of the American College of Surgeons
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