Isovolemic hemodilution with dextran prevents contrast medium induced impairment of pancreatic microcirculation in necrotizing pancreatitis of the rat
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Acute Pancreatitis: Etiology, Clinical Presentation, Diagnosis, and Therapy
2008, Medical Clinics of North AmericaCitation Excerpt :The adequacy of the rehydration is monitored (Box 5). The hematocrit may decline mildly with rehydration because of hemodilution [146]. In patients who have mild to moderate pancreatitis, rehydration does not require invasive monitoring.
Endothelin receptor blockade in severe acute pancreatitis leads to systemic enhancement of microcirculation, stabilization of capillary permeability, and improved survival rates
2000, SurgeryCitation Excerpt :However, it is one of the most powerful vasoactive substance that we have tested. At least in our model, the effect seen with ET-RA was superior to other therapeutic tools, including hemodilution therapy, platelet-activating factor receptor blockade, and intercellular adhesion molecule-1 antibodies. 27,35,36 Many experts consider endothelin to be decisive in the regulation of organ perfusion in severe pathologic conditions (eg, shock, sepsis) because it controls capillary blood flow by arterial vasoconstriction and simultaneously influences capillary permeability, probably by activating contractile elements (actin, mysin) that open gaps in the endothelial cells. 37,38
Therapy for Microcirculatory Disorders in Severe Acute Pancreatitis: Effectiveness of Platelet-Activating Factor Receptor Blockade vs. Endothelin Receptor Blockade
1999, Journal of Gastrointestinal Surgery