Biochemical and Biophysical Research Communications
Benzodiazepine-like molecules, as well as other ligands for the brain benzodiazepine receptors, are relatively common constituents of plants
References (20)
- et al.
Biochem. Biophys. Res. Commun.
(1988) - et al.
Biochem. Pharmacol.
(1988) - et al.
Biochem. Pharmacol.
(1988) - et al.
Phytochemistry
(1985) Prog. Drug Res.
(1978)- et al.
- et al.
- et al.
Receptor binding in drug research
- et al.
J. Neural Transm.
(1986) - et al.
J. Neural Transm.
(1987)
Cited by (81)
German chamomile
2021, Nutraceuticals: Efficacy, Safety and ToxicityEndozepines and their receptors: Structure, functions and pathophysiological significance
2020, Pharmacology and TherapeuticsCitation Excerpt :BZ-like molecules have been isolated by affinity chromatography using a monoclonal antibody to clonazepam from the rat (Sangameswaran & De Blas, 1985), mouse (De Blas & Sangameswaran, 1986) and bovine brain (Sangameswaran, Fales, Friedrich, & De Blas, 1986) as well as from the brain of human who had never been treated with BZs (De Blas, Park, & Friedrich, 1987). It has been hypothesized that these compounds may originate from food inasmuch as BZs are present in milk (Medina, Peña, Piva, Paladini, & De Robertis, 1988), in a number of plants (Kavvadias et al., 2000; Klotz, 1991; Medina, Peña, Levi de Stein, Wolfman, & Paladini, 1989; Unseld, Krishna, Fischer, & Klotz, 1989; Wildmann et al., 1987, 1988) and in various microorganisms (Gerlach, Schwelle, Lerbs, & Luckner, 1985; Leimgruber, Batcho, & Schenker, 1965; Waller & Dermer, 1981). However, BZs are also present in NG108-15 glioma cells that have been cultured for 3 months in serum-free medium, suggesting that these molecules may have a natural origin (De Blas et al., 1987), although the enzymatic pathway involved in their biosynthesis in brain tissue remains unknown (Sand et al., 2000).
Comparison of the effects of Origanum vulgare with LHRH-A<inf>2</inf> and 17β-estradiol on the ultrastructure of gonadotroph cells and ovarian oogenesis in immature Trichogaster trichopterus
2015, Animal Reproduction ScienceCitation Excerpt :Phytoestrogen apigenin in O. vulgare is recognized as antagonist of γ-aminobutyric acid receptor (Medina et al., 1989), stimulator of gonadotroph cells, and estrogen receptor beta agonist (Jarry et al., 2006). Inhibition of γ-aminobutyric acid stimulates LHRH and releases LH (Medina et al., 1989). Biochanin A is another phytoestrogen of this plant.
Hesperidin, a flavonoid glycoside with sedative effect, decreases brain pERK1/2 levels in mice
2009, Pharmacology Biochemistry and BehaviorAssessment of luteolin (3′,4′,5,7-tetrahydroxyflavone) neuropharmacological activity
2008, Behavioural Brain ResearchScreening of plants used in Danish folk medicine to treat epilepsy and convulsions
2006, Journal of Ethnopharmacology