Liver, Pancreas, and Biliary TractHepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B☆,☆☆
Section snippets
Patients and HBsAg carriers
Serum samples were obtained from 270 chronic HBV carriers with long-term follow-up at the gastroenterological clinics of the National Taiwan University Hospital. They included 100 asymptomatic HBsAg carriers who had persistently normal serum alanine aminotransferase (ALT) levels for at least 3 years in periodic biochemical examinations (every 3 or 6 months) and were considered asymptomatic HBsAg carriers and 170 HBsAg-positive patients with histologically verified chronic liver disease and HCC
Results
The demographic and clinical data in the 100 asymptomatic HBsAg carriers and 170 HBsAg-positive patients with various liver diseases are shown in Table 1. No significant difference in male-to-female ratios was observed in the 6 groups, mean age was significantly higher in HCC patients (P < 0.001), and serum ALT level and positive HBeAg rate were significantly higher in patients with moderate-to-severe chronic hepatitis than in other groups (P < 0.001).
The genotype distribution in the 270 HBV
Discussion
The entire nucleotide sequences of human HBV genomes of various subtypes have been classified into 6 genotypes, designated A–F.9, 10 Several studies have proposed the geographic distribution of each genotype.13, 14, 19, 20 Genotype A is the predominant genotype in northern Europe; genotypes B and C are confined to populations with origins in eastern Asia and the Far East; genotype D is found worldwide, but prevails in the Mediterranean area, the Near and Middle East, and south Asia; genotype E
Acknowledgements
The authors thank Dr. Mu-Zon Wu at the Department of Pathology of National Taiwan University Hospital for grading the degree of hepatic inflammation and fibrosis.
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Supported by grants from the Department of Health and the National Science Council, Executive Yuan, Taiwan.
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Address requests for reprints to: Ding-Shinn Chen, M.D., Hepatitis Research Center, National Taiwan University Hospital, 1 Chang-Te Street, Taipei, Taiwan 100. e-mail: [email protected]; fax: (886) 2-23317624.