Metabolism of alcohol by human gastric cells: Relation to first-pass metabolism
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Octreotide-based therapies effectively protect mice from acute and chronic gastritis
2022, European Journal of PharmacologyCitation Excerpt :In south America and Asia, around half of people are suffering from gastritis and it is brought on by multiple pathogenesis, including non-steroidal anti-inflammatory drugs (NSAIDs), alcohol consumption and Helicobacter pylori (H. pylori) infection (Eshraghian, 2014). It is believed that alcoholism is a common clinical diagnosis of erosive gastritis and alcoholic liver diseases that can generate acute damage to gastric mucosa, making the mucosa vulnerable to gastric acid, various digestive enzymes, bile, etc (Haber, 2000; Haber et al., 1996). In addition, ethanol can increase the expression of gastrin in antrum, thereby promoting gastric acid secretion (Kusterer et al., 1994).
Inhibition of human alcohol and aldehyde dehydrogenases by aspirin and salicylate: Assessment of the effects on first-pass metabolism of ethanol
2015, Biochemical PharmacologyCitation Excerpt :At 1.5 mM aspirin, the inhibitions of ADH activities were low (<5.1%) except for ADH2 (21%) and ADH1A (65%). Since ethanol concentrations in stomach fluid in a social drinking setting may reach 200 mM or higher [18,40], the inhibition of gastric ADH4 activity at 200 mM ethanol by 1.5 mM aspirin and salicylate were assessed to be 0.26% and 4.0%, respectively. At 10 μM acetaldehyde, 1.5 mM salicylate considerably inhibits activities of ALDH1A1 (71%) and ALDH2 (73%) but the inhibitions by 1.5 mM aspirin are considerably reduced, that is, 9.8% and 27%, respectively.
Inhibition of human alcohol and aldehyde dehydrogenases by cimetidine and assessment of its effects on ethanol metabolism
2013, Chemico-Biological InteractionsCitation Excerpt :Recently cimetidine has been shown to have potential anticancer effects [10]. Chronic use of cimetidine and alcohol are commonly associated, but studies on their interaction and the influences on first-pass and systemic metabolism of ethanol are controversial [1,11–17]. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are the principal enzymes responsible for metabolism of ethanol in humans, catalyzing conversion of ethanol to acetaldehyde and then to acetate, respectively [18,19].
Alcohol and gastrointestinal tract function
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