Bromelain prevents secretion caused by Vibrio cholerae and Escherichia coli enterotoxins in rabbit ileum in vitro
References (0)
Cited by (36)
Pineapple (Ananas comosus)
2018, Nonvitamin and Nonmineral Nutritional SupplementsDietary bromelain-C.3.4.22.32 supplementation improves performance and gut health in sows and piglets
2015, Livestock ScienceCitation Excerpt :Therefore, fecal E. coli and Lactobacillus counts were investigated herein and we observed that lactating sows fed BR supplemented diets had both linearly and quadratically reduced E. coli populations. Evidence has suggested that bromelain counteracts some of the effects of certain intestinal pathogens such as Vibrio cholera and E. coli (Mynott et al., 1996; Spitzer et al., 2014) by interacting with intestinal secretory signaling pathways (Mynott et al., 1996, 1997; Spitzer et al., 2014), leading to anti-adhesion effects which prevent the bacteria from attaching to specific glycoprotein receptors located on the intestinal mucosa through proteolytic modification of the receptor attachment sites (Chandler and Mynott, 1998; Mynott et al., 1999). In addition, feeding lactating sows a diet supplemented with BR linearly increased Lactobacillus counts in sows.
Production of plant proteases in vivo and in vitro - A review
2011, Biotechnology AdvancesCitation Excerpt :Bromelains are a complex of natural CPs derived from pineapple stem that are marketed for oral use as medical aid. They have been shown to inhibit the action of cholera toxin (Mynott et al., 1997), have antitumor activity, stimulating deficient monocytic cytotoxicity and inducing specific cytokines of tumor patients (Eckert et al., 1999), promote wound healing by reducing bruising and pain (MacKay and Miller, 2003; Walker et al., 2002), and reduce inflammation by selectively removing certain cell surface molecules that may affect lymphocyte migration and activation (Hale et al., 2002; Manhart et al., 2002), among many other functions. Added to its anti-edematous, anti-inflammatory, anti-thrombotic and fibrinolytic activities, bromelains have proven to be safe, lacking undesired side effects after oral administration (Maurer, 2001).
Modulation of protein phosphorylation by natural products
2002, Studies in Natural Products ChemistryA high molecular weight soluble fraction of tempeh protects against fluid losses in
2007, British Journal of Nutrition