Gastroenterology

Gastroenterology

Volume 113, Issue 3, September 1997, Pages 802-807
Gastroenterology

Clustering of increased small intestinal permeability in families with Crohn's disease

https://doi.org/10.1016/S0016-5085(97)70174-4Get rights and content

Abstract

BACKGROUND & AIMS: Small intestinal permeability is increased in a proportion of patients with Crohn's disease (CD) and a subset of their healthy relatives. A primary permeability defect was postulated in the pathogenesis of the disease. The aim of this study was to identify a possible genetic pattern in the distribution of CD and/or abnormal permeability. METHODS: Differential urinary excretion of lactulose and mannitol (L/ M) in complete CD families was determined. Controls included healthy families and families with ulcerative colitis. Pedigrees were used to compare the distribution of CD and/or increased permeability. RESULTS: The L/M was significantly increased in patients with CD. Seventeen of 67 first-degree relatives (25%) had a ratio greater than the upper limit (P95 = 0.0170). Permeability results of CD families showed a highly significant familial aggregation. The lack of a genetic pattern in relation with CD and occurrence of disturbed permeability especially within generation, points toward a shared environmental factor. Five of 14 healthy spouses (36%) of patients with CD had also an increased permeability, and prevalence of increased permeability was not higher in families with known familial occurrence (P = 0.85). CONCLUSIONS: This large family study confirms an increased permeability in a subset of healthy relatives of patients with CD. However, the absence of a typical family pattern and the high prevalence in spouses is in favor of a common nongenetic factor or a subclinical disease manifestation. (Gastroenterology 1997 Sep;113(3):802-7)

References (0)

Cited by (224)

  • Sugar-sweetened beverages exacerbate high-fat diet-induced inflammatory bowel disease by altering the gut microbiome

    2023, Journal of Nutritional Biochemistry
    Citation Excerpt :

    Although the factors that activate CD8+ T cells are unclear, an increase in circulating lipopolysaccharides may be a potential driver of T-cell activation in IBD [77]. Increased intestinal permeability facilitates the translocation of bacterial products in IBD patients and their first-degree relatives and increases the levels of circulating T cells [78]. Our results provide strong evidence that a high intake of SSBs and animal fat alters the intestinal environment, thereby increasing the expression of IBD-related inflammatory markers in humans.

  • Exploring the Early Phase of Crohn's Disease

    2021, Clinical Gastroenterology and Hepatology
  • Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor

    2020, EBioMedicine
    Citation Excerpt :

    In sharp contrast, AAV-FGF19-M52-injected WT mice showed significantly less morphological alteration and decreased inflammatory infiltrates (Fig. 1i). Patients with chronic intestinal inflammation presenting with clinically and endoscopically significant colitis display various degrees of mucin-secreting goblet cells loss [45], and the epithelial barrier is often already compromised at early stages of the disease, leading to bacterial translocation and inflammation [46,47]. Therefore, we assessed this disease index in our experimental model.

View all citing articles on Scopus
View full text