Clustering of increased small intestinal permeability in families with Crohn's disease
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Sugar-sweetened beverages exacerbate high-fat diet-induced inflammatory bowel disease by altering the gut microbiome
2023, Journal of Nutritional BiochemistryCitation Excerpt :Although the factors that activate CD8+ T cells are unclear, an increase in circulating lipopolysaccharides may be a potential driver of T-cell activation in IBD [77]. Increased intestinal permeability facilitates the translocation of bacterial products in IBD patients and their first-degree relatives and increases the levels of circulating T cells [78]. Our results provide strong evidence that a high intake of SSBs and animal fat alters the intestinal environment, thereby increasing the expression of IBD-related inflammatory markers in humans.
Exploring the Early Phase of Crohn's Disease
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2021, Clinical Gastroenterology and HepatologyFibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor
2020, EBioMedicineCitation Excerpt :In sharp contrast, AAV-FGF19-M52-injected WT mice showed significantly less morphological alteration and decreased inflammatory infiltrates (Fig. 1i). Patients with chronic intestinal inflammation presenting with clinically and endoscopically significant colitis display various degrees of mucin-secreting goblet cells loss [45], and the epithelial barrier is often already compromised at early stages of the disease, leading to bacterial translocation and inflammation [46,47]. Therefore, we assessed this disease index in our experimental model.