Gastroenterology

Gastroenterology

Volume 116, Issue 4, April 1999, Pages 1015-1016
Gastroenterology

Correspondence
Glutathione S-transferase as a major autoantigen in anti-SLA–positive autoimmune hepatitis

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Abstract

GASTROENTEROLOGY 1999;116:1015-1016

Cited by (21)

  • Antibodies to soluble liver antigen/liver pancreas and HLA risk factors for type 1 autoimmune hepatitis

    2002, American Journal of Gastroenterology
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    Antibodies to actin have greater diagnostic specificity than SMAs but less sensitivity for autoimmune hepatitis, and a standardized assay for their detection is unavailable (12–14). Antibodies to soluble liver antigen (anti-SLAs) (15) and antibodies to liver pancreas (anti-LPs) (16) have identical reactivities (17), and they are highly specific markers of autoimmune hepatitis (18). We have shown previously that these antibodies, now designated as anti-SLA/LPs, occur in at least 11% of patients with type 1 autoimmune hepatitis (19) and that they are useful in securing the diagnosis in individuals who lack ANAs and SMAs (18, 19).

  • Autoantibodies in liver disease

    2001, Gastroenterology
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    Their major clinical role may be in the evaluation and reclassification of cryptogenic chronic hepatitis.47,48 Anti-LP was initially described independent of anti-SLA,46 and only recently has its identity to anti-SLA been recognized.49,124 Consequently, anti-LP can be expected to have the same clinical utility as anti-SLA, and the designation anti-SLA/LP replaces the previous terms anti-LP and anti-SLA.

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