Selected SummariesGlial cells, mucosal integrity, and inflammatory bowel disease
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Although a disturbance of intestinal function is an expected outcome of ablation of enteric glial cells, profound structural abnormalities similar to those of idiopathic inflammatory bowel disease are surely a surprise. A diversity of animal models of inflammatory bowel disease have been generated within the past decade, most of which involve some gene-targeted or other manipulation of either the immune system (Gastroenterology 1994;107:312–314) or the epithelial barrier (Gastroenterology
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