New Methods & MaterialsHigh-resolution imaging of the human esophagus and stomach in vivo using optical coherence tomography☆,☆☆
Section snippets
METHODS
As in US imaging, OCT uses an interrogating beam that is focused to a narrow diameter within the sample. The fraction of light that is reflected backward to the emitter is detected. In US, the temporal delay between the emission of the interrogating beam and the detection of the reflection is measured to determine the distance from the emitter to the reflection site. In OCT, the temporal delay is too brief to be measured electronically. Instead, OCT measures the path length traveled by the
Normal esophageal mucosa
It was possible to clearly delineate five anatomic layers in the OCT images of normal esophagus acquired in vivo (Fig. 2).
DISCUSSION
This study represents the first clinical application of OCT in the United States for imaging of the GI tract and provides the highest resolution images ever obtained endoscopically. Comparisons of histology and OCT images indicate that OCT provides morphologic and diagnostic information. Both the high resolution of OCT and the inherent contrast provided by the differences in the reflectance of cellular and extracellular constituents in tissue contribute to the quality of the images produced.
Acknowledgements
We thank William Puricelli, RN, for technical assistance.
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Supported in part by the Whitaker Foundation, the Medical Free Electron Laser Program, Office of Naval Research, and by a grant from the Partners' Center for Innovative Minimally Invasive Therapy.
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Reprint requests: Brett E. Bouma, PhD, MGH-BAR 703, 50 Blossom St., Boston, MA 02114.