CD14-lipopolysaccharide receptor activity in hepatic macrophages after cholestatic liver injury*
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Cited by (42)
Endotoxin potentiates hepatocyte apoptosis in cholestasis
2002, Journal of the American College of SurgeonsMacrophage phenotype during cholestatic injury and repair: The persistent inflammatory response
2001, Journal of Pediatric SurgeryCitation Excerpt :Monoclonal antibodies MAC-116 and OX-317 recognize the CD11b/CD18 receptor (ICAM) and the class II major histocompatibility antigen, respectively. Previously, we and others have used immunohistochemical studies to indicate that during injury, hepatic macrophages upregulate systemic markers such as MAC-1, OX-3, and CD14.11,15 In sham-operated animals (normal conditions), resident hepatic macrophages do not express these receptors.
Immunosuppression as adjuvant therapy for biliary atresia
2001, Journal of Pediatric SurgeryCitation Excerpt :Deterioration in liver function even after a successful Kasai procedure may represent the continued evolution of the underlying disease process with progressive mononuclear cell destruction of intrahepatic bile ducts and liver parenchyma little affected by the surgical procedure itself.30 The inflammatory insult may be augmented further by episodes of recurrent ascending cholangitis or persistent biliary obstruction at the ductule level with continued bile salt-induced cholestatic injury.31-34 Capable of working through a number of mechanisms, steroids have been shown to suppress adhesion molecule expression and may modulate the disease process in part by this mechanism.35
Parenteral nutrition-associated cholestasis
2001, Seminars in Pediatric SurgeryAn improved rat model of obstructive jaundice and its reversal by internal and external drainage
2001, Journal of Surgical Research
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Supported in part by grants DK46831 (T.F.T.) and DK44305 (E.S.F.) from the National Institutes of Health, National Institute of Diabetes, Digestive and Kidney Diseases.
Presented at the Fifty-sixth Annual Meeting of the Society of University Surgeons, Denver, Colo., Feb. 9–11, 1995.