7th Alexis Carrel ConferencesPharmacokinetic characteristics of methylprednisolone in korean renal transplant recipients
Section snippets
Patients and methods
This study included 23 renal transplant recipients, 13 males and 10 females, who received kidneys from living donors, had stable graft function continuously without an episode of acute rejection, and in whom 15 to 21 days had elapsed since the time of transplantation. They had received triple immunosuppressive therapy consisting of cyclosporine (CyA), azathioprine, and prednisolone. Prednisolone was given at 90 mg on the first day after transplantation, tapered by 10 mg/d to 20 mg at day 8,
Results
The mean age of these patients was 40.2 ± 12.1 years and the mean serum creatinine level (sCr) was 1.50 ± 0.39 mg/dL. Mean body weight (BW) was 53.9 ± 9.8 kg. Mean follow-up time was 73.6 ± 13.7 weeks. There was significant interpatient variation in the pharmacokinetics of m-PDS in our group of patients. The area under the curve (AUC; ng/h/mL) was significantly related to the BW (−22.4 × BW [kg] + 2695; r = .427; P < .05) or body surface area (BSA) of each patient (−1424 × BSA [m2] + 3690; r =
Conclusions
We found significant interpatient variation in the pharmacokinetics of m-PDS in Korean renal transplant recipients who had relatively stable allograft function during the early posttransplantation period. There are significant relations between AUC and BW or BSA. However, the values of correlation coefficient were low and there was a large difference between estimated AUC and actual AUC in some patients. Therefore, it may be undesirable to give m-PDS solely based on BW or BSA of each patient.
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