Elsevier

Advances in Immunology

Volume 72, 1999, Pages 325-380
Advances in Immunology

Integrins in the Immune System

https://doi.org/10.1016/S0065-2776(08)60024-3Get rights and content

Publisher Summary

This chapter discusses the principles governing the integrins, their capacity to recognize ligands, cellular regulation of integrin function, and aspects of integrin function in the immune system. The chapter brings these general principles into focus to understand the immune system and to describe how perturbation of these receptors can be used to modulate immunological responses. Integrins are heterodimers formed by combination of 17 α and 8 β subunits in humans and are important because they play key roles in the cell migration, cell adhesion, control of differentiation, and critical decisions specifying cell proliferation and programmed cell death. The remarkable information storage and retrieval capacities of the immune system employ the general machinery involved in vertebrate development. Thus, integrins play crucial roles in modulating signals generated by clonotypic receptors and as effectors in processes such as cytolytic killing and phagocytosis.

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