Elsevier

The Lancet

Volume 357, Issue 9260, 24 March 2001, Pages 933-934
The Lancet

Research Letters
Frequency of protein Z deficiency in patients with ischaemic stroke

https://doi.org/10.1016/S0140-6736(00)04218-5Get rights and content

Summary

Prothrombotic phenotype has been described in protein- Z deficient mice, but the thrombotic risk associated with protein Z deficiency in human beings is unknown. We saw a protein Z plasma concentration deficiency of about 20% in 169 patients, from two hospitals, who had ischaemic stroke, whereas the frequency in 88 controls was about 5%. We saw no increase in the frequency of protein Z deficiency in 56 patients with venous thrombophilia. However, why protein Z deficiency was only observed in arterial thrombosis remains unknown.

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    Therefore, this was not statistically significant (p = 0.79). As PZ deficiency was previously identified as an arterial but not venous thrombotic risk factor (Vasse et al., 2001), we analysed separately patients with arterial and venous thrombosis. One patient with both arterial and venous thrombosis presented first an ischemic stroke therefore he was included in the group “arterial thrombosis”.

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