Elsevier

The Lancet

Volume 358, Issue 9296, 1 December 2001, Pages 1833-1834
The Lancet

Commentary
Redefining dietary fibre: potentially a recipe for disaster

https://doi.org/10.1016/S0140-6736(01)06882-9Get rights and content

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    2017, Food Hydrocolloids
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    However, many countries allow nutrient claims to be made based on fibre content (regardless of type) alone. It is also likely that fibre, as an important structural matrix within plants, exerts some of its action as a result of its compartmentalisation of other compounds and so intake of dietary fibre from plant-based foods may not be entirely comparable to an equal amount of isolated fibre added to a food product or within a supplement (Goodlad & Englyst, 2001). At a public health level, obesity still remains a major challenge in most parts of the world (World Health Organization, 2016).

  • Polysaccharide from Lycium barbarum L. leaves enhances absorption of endogenous calcium, and elevates cecal calcium transport protein levels and serum cytokine levels in rats

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    Generally, disease of the colon mucosa is characterized by disturbances in several inflammatory cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6 (Aden et al., 2016; Yang et al., 2014). Although dietary fiber polysaccharides are thought to protect the animal colon against colorectal cancer (CRC) and certain inflammatory diseases, other studies have shown that fermentation of large amounts of rapidly fermenting polysaccharides by gut bacteria does occur in the cecum, along with increased cell proliferation and crypt fission (Goodlad & Englyst, 2001; Lu et al., 2016). However, whether fermentation of polysaccharides in the cecum affects expression of key inflammatory proteins in the intestine remains unknown.

  • Long-term effect of resistant starch on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial

    2012, The Lancet Oncology
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    Evidence shows that the individual carbohydrates (and associated food components) quantified as dietary fibre have highly characteristic physicochemical properties and very different effects on both fermentation in the large bowel and on function of the bowel mucosa.3 As a consequence, emulation of the effects of naturally occurring dietary fibre in plant-rich diets by a single type of polysaccharide, such as resistant starch, is unlikely.1,32 We are undertaking several secondary analyses, including investigation of effects of smoking behaviour and of adiposity on risk of colorectal cancer in patients with Lynch syndrome in the CAPP2 study, which will be reported elsewhere.

  • Effects of dietary lipid composition and inulin-type fructans on mineral bioavailability in growing rats

    2009, Nutrition
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    Furthermore, these effects were concomitant with greater crypt cellularity (Table 3), which is probably attributable to an increase in crypt cell proliferation [36]. These trophic effects are believed to be mediated by butyrate, a potent stimulator of cell division and the acknowledged major energy source of colonocytes [34–36], although this assumption is still questionable and some investigators have argued about the beneficial effects of butyrate [37,38]. In this context, a previous study showed an increase in the depth and number of total and bifurcated crypts in the cecum of rats fed 7.5% low-DP ITF from yacon (Smallanthus sonchifolius) tuberous roots [3].

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