HEPATIC INJURY IN ADULT CŒLIAC DISEASE
References (12)
- et al.
Clins Gastroent.
(1974) - et al.
Lancet
(1976) - et al.
Gastroenterology
(1960) - et al.
Lancet
(1971) Clins Gastroent.
(1974)
Cited by (158)
Celiac disease: A rare cause of cirrhotic portal hypertension - A case report
2024, Gastroenterology and EndoscopyLiver in Systemic Disease
2023, MacSween's Pathology of the Liver, Eighth EditionThe tight junction and the epithelial barrier in coeliac disease
2021, International Review of Cell and Molecular BiologyCitation Excerpt :Intestinal inflammation and barrier impairment may facilitate the circulation of toxins, antigens, cytokines and/or other mediators of liver injury through the vascular system to the liver (Bardella et al., 1995). It is also believed that proinflammatory cytokine secretion by hepatocytes in the liver induce an amplifying loop that consist on an intestinal barrier defect that allows the passage of bacterial products which in turn aggravates the already existing liver damage (Hagander et al., 1977; Wiest et al., 2014). Although it seems that the epithelial barrier has a role in the onset of coeliac hepatitis, liver injury is not common in other intestinal disorders associated with inflammation and increased intestinal permeability and therefore, other unknown genetic or CD-specific factors may contribute in the pathogenesis.
ESPEN practical guideline: Clinical nutrition in liver disease
2020, Clinical NutritionCitation Excerpt :According to a systematic analysis [153] the hazard ratio for NAFL/NASH is 2.8 (95% CI 2.0–3.8) in celiac disease patients with and even higher in the subgroup of children (HR 4.6; 95% CI 2.3-0.1). There are several reports on improvement or even normalization of transaminases with response rates up to 75%–100% upon institution of a gluten free diet [154–158]. A case series from Finland reported on four patients with serious liver disease referred to the transplantation center in whom celiac disease was diagnosed during the evaluation.
The Liver and Celiac Disease
2019, Clinics in Liver DiseaseESPEN guideline on clinical nutrition in liver disease
2019, Clinical Nutrition