ViewpointGlucocorticoids and immune function: unknown dimensions and new frontiers
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2021, Experimental NeurologyCitation Excerpt :The secreted CRF induces adrenocorticotropin hormone (ACTH), which facilitates the secretion of glucocorticoids (GCs) (cortisol in human, corticosterone in rodent) from the adrenal cortex (Chamorro et al., 2007). Glucocorticoids downregulate pro-inflammatory mediators such as IL-1β, IL-11, IL-12, TNF-α, chemokines (IL-8), IFN-γ, prostaglandins, and nitric oxide, but upregulate anti-inflammatory mediators such as IL-4, IL-10, and TGFβ (Wilckens and De Rijk, 1997; Barrat et al., 2002). A synthetic glucocorticoid, dexamethasone, has shown strong pro-apoptotic and anti-proliferative effects in T lymphocytes (Tuosto et al., 1994).
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