Regular PaperAntibiotic-associated acute vanishing bile duct syndrome: A pattern associated with severe, prolonged, intrahepatic cholestasis
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2022, Journal of HepatologyCitation Excerpt :The definition of ductopenia has been put forward as a loss of biliary (interlobular) ducts which are seen in less than 50% of portal tracts.64 VBDS has mainly been reported in patients with jaundice and prolonged cholestasis for months or years.65–69 Some of these patients developed biliary cirrhosis, which can lead to the requirement for a liver transplantation or death.66,68,70
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2018, Clinics in Liver DiseaseCitation Excerpt :Data from the US DILIN showed that 19% of patients with definite, probably, or very likely DILI had persistent AST, ALT, or alkaline phosphatase abnormalities after 6 months, and 75% of these patients still had abnormalities 12 months after DILI onset, most of which were only minor enzyme elevations.99 On multivariable analysis, these patients were more likely to be older and to have had cholestatic DILI at onset, which historically has led to a longer recovery period and a risk of developing a vanishing bile duct syndrome.100–102 In the Spanish DILI registry, 273 of 298 patients normalized their liver tests, imaging findings, or hepatic histology within 1 year of DILI recognition.103
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