Research PaperPropranolol or endoscopic sclerotherapy in the prevention of recurrence of variceal bleeding: A prospective, randomized controlled trial*
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Cited by (66)
Pharmacotherapy plus endoscopic intervention is more effective than pharmacotherapy or endoscopy alone in the secondary prevention of esophageal variceal bleeding: a meta-analysis of randomized, controlled trials
2009, Gastrointestinal EndoscopyCitation Excerpt :An increased risk of rebleeding in a study by Lo et al31 could be attributed to large varices in the pharmacotherapy group of patients. Alexandrino et al13 demonstrated an increased risk of rebleeding with propranolol compared with sclerotherapy. However, patients in this study were randomized 15 days after their index bleed, and strict compliance to medications was not observed.
Comparison of esophageal stenoses produced by endoscopic sclerotherapy versus variceal ligation
2006, Gastroenterologia y HepatologiaAn Assessment of the Management of Acute Bleeding Varices: A Multicenter Prospective Member-Based Study
2003, American Journal of GastroenterologyCitation Excerpt :The median number of bands was five for acute bleeding and six for recurrent bleeding, which suggests that the actual number of bands placed at any one setting may be related more to the number of bands on any given multiband ligation device than to an attempt to ligate varices as completely as possible. Because of the prevailing high risk of recurrent variceal bleeding, therapy is indicated for all patients to prevent rebleeding (1–3, 25–86). The options include endoscopic and medical measures.
Portal hypertension
2001, Clinics in Liver DiseaseCitation Excerpt :Numerous controlled trials comparing β-blockers with EST been published and reviewed.70 In reference to rebleeding rates, one trial showed a benefit in favor of β-blockers,34 whereas two trials showed a benefit in favor of EST.4,8 The remaining seven trials failed to demonstrate a significant difference in rebleeding rates. In a meta-analysis of β-blockers versus EST for secondary prophylaxis, D'Amico et al concluded that the significant reduction in rebleeding rates seen with EST (pooled odds ratio [POR] = 0.68; CI, 0.50–0.80) should not be considered as definite evidence of superiority of EST over propranolol because of the substantial qualitative heterogeneity in the trials.31
Management of portal hypertension after variceal hemorrhage
2001, Clinics in Liver Disease
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Part of the results were presented at the EASL and AASLD Meetings in 1986.