Research PaperAbnormal tissue oxygenation in patients with cirrhosis and liver failure
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2016, Critical Care ClinicsCitation Excerpt :Patients with cirrhosis have hyperdynamic circulation, characterized by high cardiac output, relatively low arterial pressure, and low systemic vascular resistance. When infection develops in patients with cirrhosis, systemic circulation becomes even more hyperdynamic and hyporeactive to pharmacologic doses of alpha-adrenoreceptor agonists.32,33 Patients with cirrhosis and septic shock have higher cardiac indices, higher plasma lactate concentrations, lower temperature, and higher mortality rates as compared with patients without cirrhosis.34