Hepatitis C virus genotypes and subtypes in patients with hepatitis C, with and without cryoglobulinemia
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Cited by (77)
Advances in HCV and Cryoglobulinemic Vasculitis in the Era of DAAs: Are We at the End of the Road?
2018, Journal of Clinical and Experimental HepatologyCitation Excerpt :HCV appears to have an important etiologic role in MC, since HCV infection (serum anti-HCV antibody or HCV-RNA) can be found in 76–95% of patients with MC.33–35 On the other hand, serum cryoglobulins can be identified in 19–54% of patients with chronic HCV infection, depending on the geographical area, population selection, diagnostic method of MC, and lead-time biases.36–38 However, serum cryoglobulins are generally asymptomatic and present at low levels.
Vasculitis related to viral and other microbial agents
2015, Best Practice and Research: Clinical RheumatologyCitation Excerpt :Mutations in the N-terminal hypervariable regions 1 and 2 (HVR1 and HVR2) of the E2 envelope glycoprotein were initially thought to predispose to MC via CD81-activated proliferation of peripheral B cells [48,49]. However, viral genotyping studies have overall failed to demonstrate correlations between viral sequences and development of MC or progression of MC to symptomatic disease [50–52]. MCs are produced by marginal zone B cells of lymphoid aggregates in hepatic portal tracts primarily, but bone marrow, lymph nodes, and peripheral mononuclear cells where HCV RNA has been demonstrated may be other sources [53,54].
Leukocytoclastic vasculitis and necrolytic acral erythema in patients with hepatitis C infection: Do viral load and viral genotype play a role?
2010, Journal of the American Academy of DermatologyCitation Excerpt :Moreover, Gadet al,35 in 2003, found that HCV genotype 1b in Japanese patients was more frequently associated with cryoglobulinemia than genotype 4 in Egyptian patients, however, ethnicity and genetic factors could have played a role in their findings. Other investigators found no difference in genotype prevalence between HCV-related cryoglobulinemia and chronic HCV without cryoglobulinemia.36,37 Only 3 studies, all from the United States, have investigated HCV genotype in patients presenting with NAE.
Dermatologic Disorders Associated With Chronic Hepatitis C: Effect of Interferon Therapy
2007, Clinical Gastroenterology and HepatologyCitation Excerpt :Cryoprecipitates are rich in HCV RNA and anti-HCV.36,37 Between 25% and 50% of patients with chronic HCV have detectable cryoglobulinemia,49,50 with 10%–30% having symptoms.48–51 Conversely, up to 90% of MC patients are HCV-infected.48
Systemic vasculitis due to hepatitis C virus
2006, Bulletin de l'Academie Nationale de MedecineChronic hepatitis C: Genotypes 4 to 9
2005, Clinics in Liver Disease