Elsevier

Journal of Hepatology

Volume 25, Issue 5, November 1996, Pages 684-688
Journal of Hepatology

Serum laminin and hyaluronan in liver cirrhosis: markers of progression with high prognostic value

Dedicated to Prof. Dr. Hammar (Head of the Department of Medicine II at Städtisches Klinikum Fulda, Germany) on his 66th birthday.
https://doi.org/10.1016/S0168-8278(96)80239-XGet rights and content

Abstract

Background/Aims: In a prospective study with a mean follow-up period of 12.5±3.5 months, we investigated the extracellular matrix components laminin and hyaluronan in serum for their diagnostic value in portal hypertension and in clinically severe complications of progressive liver cirrhosis.

Methods: In 38 patients with liver fibrosis (n=4) and cirrhosis (Child A: n=17, B: n=7, C: n=10), the serum concentrations of laminin and hyaluronan were determined. Portal hypertension was assessed by endoscopic control of the esophageal varices and by Doppler sonography of the portal blood flow.

Results: Neither laminin nor hyaluronan correlated with portal hypertension, but highly significantly increased (p<0.001) concentrations of 3.25±0.2 U/ml (laminin) and 493±248 ng/ml (hyaluronan) were found in patients with complications livers cirrhosis when compared to those without complications (Ln: 2.13±0.26 U/ml, HA: 206±184 ng/ml). At cut-off levels of 2.6 U/ml (laminin) and 200 ng/ml (hyaluronan), the diagnostic sensitivity and specificity for severe complications of liver cirrhosis was 0.71 and 0.86 (Ln) and 0.90 and 0.67 (HA), respectively. The positive predictive values were of 0.8 (laminin) and 0.6 (hyaluronan). The relative risk of patients presenting elevated concentrations of laminin or hyaluronan at the start of the study for later development of severe complications was 2.7.

Conclusions: Both parameters, especially serum laminin, can be used as prognostic markers in addition to the Child criteria in liver cirrhosis.

References (26)

  • J Kropf et al.

    Logistic-regression model for assessing portal hypertension by measuring hyaluronic acid (hyaluronan) and laminin in serum

    Clin Chem

    (1991)
  • CG Child et al.

    Survey and portal hypertension

  • RNH Pugh et al.

    Transection of the oesophagus for bleeding oesophageal varices

    Br J Surg

    (1973)
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