Protein C, protein S and antithrombin III in children with portal vein obstruction
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Thrombin dynamics in children with liver disease or extrahepatic portal vein obstruction or shunt
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2016, International Journal of SurgeryMeso-Rex bypass - A procedure to cure prehepatic portal hypertension: The insight and the inside
2014, Journal of the American College of SurgeonsCitation Excerpt :All PHPH children are considered potential candidates for MRB and, therefore, all are assessed using a standardized diagnostic clinical, laboratory, and radiologic protocol, as follows. Although it is rarely associated in children, thrombophilia must be excluded by a detailed study of the coagulation, including measurement of prothrombin time; partial thromboplastin time; international normalized ratio; anti-thrombin III; factors II, V, VII, and X; protein C and S; and a search for mutations of factor V Leiden; factor II prothrombin; and methylene-tetra-hydro-folate-reductase.8-10,13 Abdominal Doppler ultrasound is used to study the liver and confirm that the parenchyma is normal in all aspects (absence of liver disease or cirrhosis), detection of liver nodes; to identify the intrahepatic portal radicals (with particular attention to the left portal vein and the Rex recessus) and possible anatomical variations; to study the abdominal venous compartment (SMV, splenic vein, splenomesenteric confluence); to measure spleen span and assess the presence of spontaneous splenorenal shunts (for follow-up purposes); and to assess other variable aspects: dilated intrahepatic bile ducts (secondary “portal biliopathy”) and gallbladder varices, together with the presence of gallstones and sludge.
Non-cirrhotic portal hypertension - Diagnosis and management
2014, Journal of Hepatology