High degree of conservation in the hepatitis B virus core gene during the immune tolerant phase in perinatally acquired chronic hepatitis B virus infection
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Cited by (44)
Role of viral load in Hepatitis B virus evolution in persistently normal ALT chronically infected patients
2019, Infection, Genetics and EvolutionCitation Excerpt :Therefore, the differential substitution rates in Core between Group A and B suggest that the immune pressure drives the differential behavior of the groups, although it cannot be inferred through transaminase levels. This is in line with the finding that asymptomatic HBeAg-positive carriers showed a high degree of conservation in the Core gene, despite the high levels of viremia, while in asymptomatic HBeAg-negative carriers, with low or undetectable levels of HBV-DNA, showed a greater number of mutations (Bozkaya et al., 1997; Fujiwara et al., 1998; Seo et al., 2003). On the other hand, Pol and X genes showed lower nucleotide substitution rates, emphasizing the critical function performed by this region in HBV biology.
Detecting exact breakpoints of deletions with diversity in hepatitis B viral genomic DNA from next-generation sequencing data
2017, MethodsCitation Excerpt :Hepadnaviridae show higher evolution rates than other DNA viridae and human genomes but lower rates than RNA viridae. The evolution rates of HBV have been calculated to be in the ranges of 1–5 × 10−5 and 5–8 × 10−5 per site per year in immuno-competent patients [7], 6–18 × 10−3 in liver transplant recipients with fulminant reinfection [8], and 0.3–1.3 × 10−3 for the HBV core gene in a case of perinatally acquired chronic HBV infection [9]. More than 1011 HBV virions can be produced daily in a single patient [10].
Quasispecies characteristics in mother-to-child transmission of hepatitis B virus by next-generation sequencing
2017, Journal of InfectionCitation Excerpt :A picture of the whole HBV genome may be more convincing and can provide corroborative evidence. The results of genetic diversity within the non-overlapping pre-C/C gene of HBV show lower Sn and HD in children with no or minimal increase in ALT values compared with children who had high ALT levels or mothers who had low or high ALT levels, which is consistent with previous reports.17,42–44 These data indicate that HBV sequences are quite homogeneous during the early phase of infection and become more divergent as the disease progresses.
The Impact of Rapid Evolution of Hepatitis Viruses
2008, Origin and Evolution of Viruses, Second EditionViral Quasi-Species Evolution During Hepatitis Be Antigen Seroconversion
2007, GastroenterologyCitation Excerpt :The nonoverlapping region of the core protein shows a high level of sequence diversity, particularly after seroconversion compared with the control sequences, the precore signal sequence, and the nucleic acid binding domain of core. There have been no in-depth characterizations of HBV quasi-species with the exception of a recent study by Osiowy et al,20 although a few studies have attempted to define long-term mutation rates of HBV.21–23 The findings from the latter studies are consistent with our findings, showing that in the “immunotolerant” phase, there are few mutations but these increase during the “immunoreactive” phase.