Augmentation of the early phase of liver regeneration after 70% partial hepatectomy in rats following selective Kupffer cell depletion
References (45)
- et al.
Bidirectional effects of Kupffer cells on hepatocyte proliferation in vitro
FEBS Lett
(1991) - et al.
Non-parenchymal cells from regenerating rat liver generate IL-alpha and IL1-beta—a mechanism of negative regulation of hepatocyte proliferation
Hepatology
(1997) The liposome-mediated macrophage ‘suicide’ technique
J Immunol Methods
(1989)- et al.
Hepatotrophin mRNA expression in human foetal liver development and in liver regeneration
FEBS Lett
(1990) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
J Immunol Methods
(1983)- et al.
Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
J Immunol Methods
(1986) - et al.
Single step method of RNA extraction by acid-guanidinium-thiocyanate-phenol-chloroform extraction
Anal Biochem
(1987) - et al.
A technique for radiolabelling DNA restriction fragments to high specific activity
Anal Biochem
(1983) - et al.
Interleukin 1b is a potent growth inhibitor of adult rat hepatocytes in primary culture
Exp Cell Res
(1988) - et al.
Role of heparin-binding epidermal growth factor-like growth factor as a hepatotrophic factor in rat liver regeneration after partial hepatectomy
Hepatology
(1995)
Expression of cytokine genes during liver regeneration after partial hepatectomy in rats
J Surg Res
Kupffer cell autoregulation of IL-1 production by PGE2 during hepatic regeneration
J Surg Res
Transforming growth factor beta gene expression in normal and fibrotic rat liver
J Hepatol
Experimental pathology of the liver I: restoration of the liver of the white rat following partial surgical removal
Arch Pathol
Hepatic regeneration: current concepts and clinical implications
Semin Liver Dis.
Liver regeneration
FASEB J
Expression of transforming growth factor-alpha in regenerating liver and during hepatic differentiation
Mol Carcinog
Intrahepatic distribution of transforming growth factor-alpha (TGF alpha) during liver regeneration following carbon tetrachloride-induced necrosis
J Pathol
Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver, but not myofibroblast-like cells derived from fat-storing cells
Hepatology
Activation of hepatocyte growth factor by the plasminogen activators uPA and tPA
Am J Pathol
Hepatocyte growth factor, blood clearance, organ uptake, and biliary excretion in normal and partially hepatectomised rats
Lab Invest
Transforming growth factor beta mRNA increases during liver regeneration; a possible paracrine mechanism of growth regulation
Proc Natl Acad Sci USA
Cited by (52)
Interleukin-17A plays a pivotal role after partial hepatectomy in mice
2013, Journal of Surgical ResearchCitation Excerpt :Because insufficient liver regeneration is potentially fatal for these patients, investigation of the physiological mechanism of liver regeneration could lead to decreased morbidity and mortality, leading to increased opportunities for therapy against critical liver disease. The hepatic macrophage, the Kupffer cell, is known to produce a variety of growth and immunomodulating mediators that have stimulatory and inhibitory effects on liver regeneration [6]. It was reported that hepatic macrophages are the major source of tumor necrosis factor (TNF)-α and interleukin (IL)-6 and depletion of hepatic macrophages impaired liver regeneration after PH [7].
The Kupffer cell inhibition exacerbates but splenectomy prevents mortality in a rat septic peritonitis model
2012, Journal of Surgical ResearchCitation Excerpt :Rats were given food and water ad libitum throughout the study. Animals received intravenous administration of 1 mL of lipo-MDP 24 h before CLP to eliminate the Kupffer cell but not the splenic macrophage [13]. Non-entrapped liposome (lipo; 1 mL/animal) was administered as a control.
Liver regeneration is impaired in macrophage colony stimulating factor deficient mice after partial hepatectomy: The role of M-CSF-induced macrophages
2011, Journal of Surgical ResearchCitation Excerpt :However, their function in liver regeneration after partial hepatectomy (PH) and the underlying mechanisms are not fully understood [12]. There are only a limited number of studies available using this Kupffer cell-depleting approach to clarify their role in liver regeneration [13–16]. Although Boulton et al. noted an augmentation of the early phase of liver regeneration following Kupffer cell depletion [16], it has also been reported that Kupffer cell depletion exerts an inhibitory effect on liver regeneration by altering hepatic cytokine expression patterns [4, 14].
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