Dietary nucleotides correct plasma and liver microsomal fatty acid alterations in rats with liver cirrhosis induced by oral intake of thioacetamide

doi:10.1016/S0168-8278(98)80291-2

Journal of Hepatology

Volume 28, Issue 4, April 1998, Pages 662-669

https://doi.org/10.1016/S0168-8278(98)80291-2 Get rights and content

Abstract

Background/Aims: Dietary nucleotides modulate a number of metabolic processes, including long-chain polyunsaturated fatty acid metabolism. In this study, we evaluated the effect of dietary nucleotides on plasma and liver microsomal fatty acid profiles in a rat model of liver cirrhosis induced by oral intake of thioacetamide.

Methods: Fifty-four female Wistar rats were assigned to one of the following groups: rats in the thioacetamide group (n=45) were given 300 mg thioacetamide/l in their drinking water for 4 months, and rats in the control group (n=9) received water during the same period. After 4 months of treatment, 9 rats in each group were killed. The remaining in the thioacetamide group were divided into two new groups, and the animals in each were allowed to recover for 1 or 2 weeks on either a nucleotide-free diet or the same diet supplemented with 50 mg of each of the following: AMP, GMP, CMP, IMP and UMP per 100 g diet.

Results: Saturated (mainly stearic acid), monounsaturated, and n-6 long-chain polyunsaturated fatty acids (mainly arachidonic acid), and also the unsaturation index decreased in plasma of rats with experimental cirrhosis. Administration of the diet supplemented with nucleotides to thioacetamides-treated rats corrected plasma levels of saturated, n-6 long-chain polyunsaturated fatty acids and the unsaturation index. In liver microsomes, the cirrhotic rats showed lower levels of protein and higher levels of palmitic, oleic, linoleic and arachidonic acids. Protein concentrations and levels of all the above-mentioned fatty acids were corrected with the nucleotide-enriched diet.

Conclusions: Dietary nucleotides contribute to correcting plasma and liver microsomal fatty acid alterations in rats with liver cirrhosis induced by chronic oral administration of thioacetamide.

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Dietary nucleotides correct plasma and liver microsomal fatty acid alterations in rats with liver cirrhosis induced by oral intake of thioacetamide

Abstract

Nutr Res

Pharmacol Ther

Hepatology

Toxicology

Am J Clin Nutr

J Nutr

Gastroenterology

Gastroenterology

Influences of postnatal age and dietary nucleotides on plasma fatty acids in the weanling rat

J Parenter Enteral Nutr

Changes in fatty acid profiles of red blood cell membranes mediated by dietary nucleotides in weanling rats

J Pediatr Gastroenterol Nutr

Effect of dietary nucleotides on the fatty acid composition of rat liver microsomes

Arch Int Biochim Biophys

Changes in the fatty acid profiles of plasma lipid fractions induced by dietary nucleotides in infants born at term

Eur J Clin Nutr

Changes in the fatty acid patterns of blood cell phospholipids induced by the type of milk, dietary nucleotides supplementation, and age in preterm infants

J Pediatr Gastroenterol Nutr

Plasma lipoproteins in suckling rats; effects of dietary nucleotides

J Clin Nutr Gastroenterol

Dietary nucleotides influence lipoprotein metabolism in newborn infants

Pediatr Res

Lipoprotein changes in small-for-gestational infants fed nucleotide-supplemented milk formula

Acta Paediatr

Dietary nucleotides enhance plasma lecithin-cholesterol acyl transferase and apolipoprotein A-IV concentration in preterm newborn infants

Pediatr Res

Effect of dietary nucleotides on growth and maturation of the developing gut in the rat

J Pediatr Gastroenterol Nutr

Effect of dietary nucleotides on intestinal repair in rats with experimental chronic diarrhea

J Parenter Enteral Nutr

Effect of dietary nucleotides on small intestinal repair after diarrhea. Histological and ultrastructural changes

Gut