Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population

doi:10.1016/S0304-3940(99)00098-1

Neuroscience Letters

Volume 263, Issues 2–3, 26 March 1999, Pages 205-207

https://doi.org/10.1016/S0304-3940(99)00098-1 Get rights and content

Abstract

Recently a relationship between serotonin transporter transcriptional control region (5-HTTLPR) polymorphism and anxiety related personality traits in Caucasians was reported. We performed PCR of DNAs from the blood for determining the 5-HTTLPR genotypes of 191 Japanese subjects, which were medical staff and students, and obtained Revised NEO Personality Inventory (NEO-PI-R) and the Temperament and Character Inventory (TCI) in 144 subjects. The association was analyzed by one-way ANOVA. The present study demonstrated that allelic frequency of 5-HTTLPR (s allele frequency was 0.785) in our subjects was considerably different from that in Caucasians. No significant differences were found in the anxiety-related personality traits among genotypes, while cooperativeness in TCI showed a significant difference among genotypes. The property of 5-HTTLPR may not be reflected directory on the personality inventories.

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Citation Excerpt :
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Study of the association between the serotonin transporter gene regulatory region polymorphism and personality traits in a Japanese population

Abstract

A systematic method for clinical description and classification of personality variants: a proposal

Arch. Gen. Psychiatry

A psychobiological model of temperament and character

Arch. Gen. Psychiatry

No association between the serotonin transporter gene regulatory region polymorphism and the Tridimensional Personality Questionnaire (TPQ) temperament of harm avoidance

Mol. Psychiatry

Allelic variation of human serotonin transporter gene expression

J. Neurochem.

An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population

Psychiatry Clin. Neurosci.

Cloninger's seven factor model of temperament and character and Japanese version of Temperament and Character Inventory (TCI)

Jpn. J. Psychiatr. Diagn.