Editorial overviewInnate immunity
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Ruslan Medzhitov is interested in the analysis of innate immune recognition and its control of the adaptive immune responses.
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Cited by (30)
The function of serpin-2 from Eriocheir sinensis in Spiroplasma eriocheiris infection
2018, Fish and Shellfish ImmunologyCitation Excerpt :The S. eriocheiris was mainly seen in the hemocytes in the early processes of infection, and then transported to various tissues and organs by hemocytes [3]. Due to lack adaptive immunity, the crabs' innate immune response played a vital role in protecting hosts from invading pathogens [4,5]. Therefore, it was essential to research about innate immune-related genes of E. sinensis against S. eriocheiris to control the TD.
Chemotactic effect of β-defensin 1 on macrophages in Megalobrama amblycephala
2018, Fish and Shellfish ImmunologyCitation Excerpt :Furthermore, in humans and birds, β-defensins possess six conserved cysteines located in a single exon, whereas in fish these six cysteines are divided between two exons [19]. Immune responses in vertebrates, invertebrates and plants are initiated by the recognition of pathogens by the cells of the innate immune system [20,21]. Phagocytes are an important component in the nonspecific defense against infection [22].
Cyclooxygenase and cytokine regulation in lung fibroblasts activated with viral versus bacterial pathogen associated molecular patterns
2013, Prostaglandins and Other Lipid MediatorsCitation Excerpt :Inflammatory cytokine release is driven, to a significant degree, by innate immune pathways. The innate immune system is an integral and complex interaction of multiple cell types, receptor signaling pathways and cytokines that promote an inflammatory response and trigger adaptive immune components to boost clearance of invading pathogens [14]. Pattern recognition receptors (PRR), such as Toll-like receptors (TLRs), are key in this process.
P53 Superfamily Proteins in Marine Bivalve Cancer and Stress Biology
2011, Advances in Marine BiologyCitation Excerpt :Haemocyte cancer in clams is an example of a transplantable tumour that is not hampered by two of the characteristics that limit the applicability of mouse transplantable tumour models (Ostrand-Rosenberg, 2004; Walker et al., 2009). For example, histocompatibility is not an issue since clams have only innate immunity (Medzhitov and Biron, 2003) and tumour cell inoculation is not subcutaneous as it is in mouse models, but occurs in an anatomically appropriate site for the tumour (the clam circulatory system) (Walker et al., 2009). Cancerous clam haemocytes provide excellent in vivo and in vitro models for human and other animal cancers displaying cytoplasmic sequestration of the p53 tumour suppressor by mortalin tethering.
Antimicrobial activity-specific to Gram-negative bacteria and immune modulation-mediated NF-κB and Sp1 of a medaka β-defensin
2009, Developmental and Comparative ImmunologyEffect of cefodizime on cytokines expression in mouse neutrophils and its related mechanism
2008, Journal of Medical Colleges of PLA
Ruslan Medzhitov is interested in the analysis of innate immune recognition and its control of the adaptive immune responses.
Christine Biron’s research interests are directed towards understanding the cellular and cytokine mechanisms regulating immune defenses, with particular emphasis on natural killer (NK) and T cell responses elicited during acute viral infections.