Linkage disequilibrium mapping of complex disease: fantasy or reality?

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Abstract

In the past year, data about the level and nature of linkage disequilibrium between alleles of tightly linked SNPs have started to become available. Furthermore, increasing evidence of allelic heterogeneity at the loci predisposing to complex disease has been observed, which has lead to initial attempts to develop methods of linkage disequilibrium detection allowing for this difficulty. It has also become more obvious that we will need to think carefully about the types of populations we need to analyze in an attempt to identify these elusive genes, and it is becoming clear that we need to carefully reevaluate the prognosis of the current paradigm with regard to its robustness to the types of problems that are likely to exist.

Abbreviations

+ not carrying disease-predisposing alleles
D disease-predisposing allele
LD linkage disequilibrium
SNP single nucleotide polymorphism
TDT transmission/disequilibrium test

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