The inhibitory ankyrin and activator Rel proteins

doi:10.1016/S0959-437X(05)80276-X

Current Opinion in Genetics & Development

Volume 2, Issue 2, 1992, Pages 211-220

https://doi.org/10.1016/S0959-437X(05)80276-X Get rights and content

The gene families encoding the proteins NF-ℵB, c-Rel and Dorsal, in conjunction with their respective inhibitors IℵB, pp40, and Cactus, achieve specificity in gene regulation by means of common principles. The related activities of NF-ℵB and Dorsal are mediated by heterodimeric or homodimeric complexes of proteins containing the conserved dimerization and DNA-binding domain termed Rel. The IℵBs and Cactus, which share a core series of structural repeats termed ankyrin, inhibit cognate activators through differential interactions with the Rel-homology domain. Together, the inhibitory ankyrin proteins and their cognate Rel dimers probably define specific signalling pathways able to activate specific gene expression. Both gene families include proto-oncogenes, thus broadly implicating Rel/IℵB in the control of both normal gene expression and the abberant gene expression that makes cells cancerous.

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The inhibitory ankyrin and activator Rel proteins

Cell

Cell

Oncogene

Nature

EMBO J

Oncogene

AIDS Res Hum Retroviruses

The Physiology of the NF-ℵB Transcription Factor

Malignant Transformation by Mutant rel Proteins

Trends Genet

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Trends Cell Biol

Cloning of the p50 DNA Binding Subunit of NF-ℵB: Homology to Rel and Dorsal

Cell

Analysis of cDNA for Human Erythrocyte Ankyrin Indicates a Repeated Structure with Homology to Tissue-differentiation and Cell-cycle Control Proteins

Nature

TAN-1, the Human Homologue of the Drosophila Notch Gene, is Broken by Chromosomal Translocations in T Lymphoblastic Neoplasms

Cell

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Science

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Cell

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Science

The v-rel Oncogene Encodes a ℵB Enhancer Binding Protein that Inhibits NF-ℵB Function

Cell

NF-ℵB: a Family of Inducible and Differentially Expressed Enhancer-binding Proteins in Human T Cells