Thalidomide analogs and PDE4 inhibition

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Abstract

N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-α are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.

N-Phthaloyl 3-amino-3-arylpropionic acid analogs of thalidomide that are potent inhibitors of tumor necrosis factor-α are reported. These compounds were found to be potent inhibitors of phosphodiesterase 4.

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