Trends in Microbiology
ReviewInteractions between enteropathogenic Escherichia coli and host epithelial cells
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Cited by (215)
Post-transcriptional regulation in attaching and effacing pathogens: integration of environmental cues and the impact on gene expression and host interactions
2021, Current Opinion in MicrobiologyCitation Excerpt :LEE expression results intimate adherence of AE pathogens to enterocytes and the formation of AE lesions. AE lesions are characterized by the effacement of the microvilli and rearrangement of underlying host cytoskeleton resulting in the production of a pedestal-like structure beneath the bacterium [14]. AE pathogens include enteropathogenic Escherichia coli (EPEC), enterohemorrhagic E. coli (EHEC), and Citrobacter rodentium.
Adherence patterns of Escherichia coli in the intestine and its role in pathogenesis
2020, Medicine in MicroecologyTranscriptional and posttranscriptional regulation of the locus of enterocyte effacement in Escherichia albertii
2019, Microbial PathogenesisDevelopment of an HTS system to identify natural chemicals that specifically inhibit Escherichia coli O157:H7 adhesion to host cells
2017, Food ControlCitation Excerpt :Adhesion of E. coli O157:H7 to intestinal epithelial cells causes serious diseases such as severe diarrhea and hemorrhagic colitis, which can lead to the life-threatening hemolytic-uremic syndrome (HUS) (Tarr, Gordon, & Chandler, 2005). A distinctive histopathology in host intestinal cells is attaching and effacing (A/E) lesions which are characterized by the loss of microvilli, an intimate adherence of bacteria adjacent to the host cell membrane, and the generation of an organized cytoskeletal structure containing filamentous actin beneath adherent bacteria, which is called an actin pedestal (Donnenberg, Kaper, & Finlay, 1997). The genes involved in the formation of these lesions are encoded by the Locus of Enterocyte Effacement (LEE) pathogenicity island, which is 30,919-bp in size.
Shiga Toxin Producing Escherichia coli
2015, Clinics in Laboratory MedicineCitation Excerpt :Eae forms part of the conserved “locus of enterocyte effacement” (LEE).37 The LEE encodes a series of proteins inducing cytoskeletal changes in the eukaryotic target cell that enhance attachment and effacement of the bacterium, and a type III secretion system to deliver them.38 The LEE system increases virulence of STEC, but it is not found in all STEC strains39; other adhesive agents are known but are not as well-characterized.40,41
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