Immunity
ArticleInteractions between stem cell factor and c-Kit are required for intestinal immune system homeostasis
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Understanding the complexities of SARS-CoV2 infection and its immunology: A road to immune-based therapeutics
2020, International ImmunopharmacologyCitation Excerpt :Thus, CD8+T cells response is weaker in asymptomatic patients of COVID-19. Also, the SCF-c-kit (CD117) interaction maintains gut immune homeostasis and thus asymptomatic SARS-CoV2 people may not be showing gastrointestinal disturbance, an area remains to explore [174]. LIF also suppresses the IFN-γ release from T cells, promotes FoxP3+ regulatory T (Tregs) and Th2 cell proliferation, suppresses Th17 cells, and exerts host protective anti-inflammatory effects opposite to the pro-inflammatory cytokine, IL-6 (Fig. 3) [175–178].
Mast cells drive IgE-mediated disease but might be bystanders in many other inflammatory and neoplastic conditions
2019, Journal of Allergy and Clinical ImmunologyAn epithelial armamentarium to sense the microbiota
2013, Seminars in ImmunologyCitation Excerpt :Finally, unlike conventional T cells, IELs are antigen-experienced T cells that do not require priming, and immediately release cytokines and cytotoxic granules to kill infected cells [175,176]. Given that a large number of IELs reside in close contact with neighboring IECs, perhaps it is not surprising that functional cross-talk between IECs and IELs exists [177–179]. Indeed, IELs has been shown to play a critical role in the homing of IELs to the intestinal epithelium by expressing the ligand CCL25, which interacts with the chemokine receptor CCR9 expressed on the surface of IELs [180,181].