Elsevier

Microbes and Infection

Volume 3, Issues 14–15, November–December 2001, Pages 1327-1334
Microbes and Infection

Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity

https://doi.org/10.1016/S1286-4579(01)01494-0Get rights and content
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Abstract

Resistance to innate immunity is essential for salmonellae pathogenesis. The salmonellae PhoP/PhoQ regulators sense host environments to promote remodeling of the bacterial envelope. This remodeling includes enzymes that modify lipopolysaccharide (LPS). Modified LPS promotes bacterial survival by increasing resistance to cationic antimicrobial peptides and by altered host recognition of LPS.

Keywords

Salmonella
pho-phoQ
LPS
membrane remodeling
antimicrobial peptides
innate immune system
resistance

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