Intestinal iron absorption: current concepts circa 2000
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Effect of hepcidin antagonists on anemia during inflammatory disorders
2021, Pharmacology and TherapeuticsCitation Excerpt :It additionally contributes towards maintaining redox homeostasis by regulating excessive levels of primary toxicants that are responsible for the generation of reactive oxygen species (ROS), cellular damage and death (Dixon & Stockwell, 2014). An adult human absorbs 1–2 mg iron per day from daily diet for compensation of daily iron loss due to blood loss, epithelial cell shedding in digestive tract and sweating (Andrews, 2000). Iron from the diet is absorbed in two different forms, non-heme iron (organic): present mainly in vegetables/pulses/grains, and heme iron (ferrous iron protoporphyrin IX): present in animal tissue (Johnson-Wimbley & Graham, 2011) (Fig. 1).
Role of transferrin: An iron-binding protein in health and diseases
2021, Nutraceuticals: Efficacy, Safety and ToxicityClassification and structural analyses of mutational landscapes in hemochromatosis factor E protein: A protein defective in the hereditary hemochromatosis
2017, Gene ReportsCitation Excerpt :The hereditary hemochromatosis (HH) or iron overloading is attributed to the erroneous regulation of iron homeostasis inside the body (Andrews, 2000b; Bacon, 1996; Kell, 2009). This unusual increase in the iron levels is caused by elevated iron absorption from the small intestine and progressive deposition in vital organs including liver (Andrews, 2000a). The initial infection leads to the development of cirrhosis conditions in the liver results in the development of hepatocellular carcinoma (Fleming and Sly, 2002; Lv et al., 2016a).
Trace elements in human physiology and pathology. Copper
2003, Biomedicine and PharmacotherapyCadmium transport by human Nramp 2 expressed in Xenopus laevis oocytes
2003, Toxicology and Applied PharmacologyMolecular aspects of duodenal iron absorption
2003, Gastroenterologia y Hepatologia