Brief Clinical ObservationPancreatic hyperenzymaemia and hypertransaminasaemia in healthy subjects: Report of three cases
Introduction
We recently described an anomalous increase in serum pancreatic enzymes in healthy subjects in the absence of any disease [1], [2]. An increase in serum transaminases in the absence of hepatic diseases has also been reported by various authors [3], [4], [5], [6], [7], [8], [9], [10], [11], [12]. This hypertransaminasaemia may be found in patients with occult coeliac disease [3], [4], [5], [6], diabetes [7], thyroid disorders [8] or Addison’s disease [9], [10], [11], [12], but also in subjects with no apparent pathological conditions [4]. The simultaneous occurrence of pancreatic hyperenzymaemia and hypertransaminasaemia in three healthy subjects is reported herein, this being the first description of this association.
Section snippets
Case report
A 39-year-old male and a 30-year-old female from Bologna, Italy, and a 27-year-old white male from Washington, DC, USA, were referred to us for diagnostic work-up after they were found to have asymptomatic elevated serum amylase and lipase in addition to elevated transaminases. These abnormal laboratory values were initially revealed in the course of general medical check-ups carried out from 2 to 6 years (mean 4.3), prior to referral to us. At that time, all other laboratory findings,
Discussion
We have presented three cases of healthy subjects with elevated serum levels of amylase, lipase and transaminases. These elevations, at times, reached very high levels but were not constant, and sometimes returned to normal. The results of all of the pancreatic and hepatic examinations performed in these three subjects, both functional and imaging, including two liver biopsies in one of the three, were normal, indicating that the chronic pancreatic hyperenzymaemia and the hypertransaminasaemia
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Healthy Chinese with benign pancreatic hyperenzymemia
2015, Journal of the Chinese Medical AssociationCitation Excerpt :Finally, this patient was diagnosed with benign pancreatic hyperenzymemia after an observation period of about 2 years without symptoms of pancreatic diseases or structural changes. Pancreatic hyperenzymemia is common in pancreatic diseases and also occurs in nonpancreatic etiologies such as renal failure, brain trauma, traumatic shock, postoperative diabetic acidosis, renal transplants, pneumonia, pregnancy, and macroamylasemia.3,7 However, elevated pancreatic enzymes could be a nonspecific phenomenon without any clinical implication.8
Benign pancreatic hyperenzymemia
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2003, Digestive and Liver DiseaseBenign pancreatic hyperenzymemia or Gullo's Syndrome: Incidence in patients admitted to an emergency department
2016, Gazzetta Medica Italiana Archivio per le Scienze MedicheHow to interpret amylase and lipase dosages?
2013, Hepato-Gastro