Original investigationCT Colonography: Effect of Colonic Distension on Polyp Measurement Accuracy and Agreement—In Vitro Study
Section snippets
Materials and methods
Full ethical committee approval was obtained for the study. A 16-year-old male with familial adenomatous polyposis coli scheduled to undergo elective colectomy was identified from the polyposis registry database at our institution and approached by the study coordinator before colectomy. Full written consent for use of the colectomy specimen was obtained from the patient and his parents. Throughout the study, care was taken to ensure that the experiment did not interfere with subsequent
Results
A total of 23 polyps (4 mm [x1], 5 mm [x11], 6 mm [x6], 7 mm [x2], 8 mm [x2], and 15 mm [x1]) were visible on both datasets and included in the analysis. All polyps were classified as sessile.
Discussion
Validation of polyp size measurement accuracy and quantification of inter- and intraobserver measurement agreement is vital if CTC is to become established as a primary screening modality, with an active role in polyp follow-up.
Recent data have questioned the reliability of measurements using CTC (10), but have used mainly endoscopic estimates of polyp size, rather than exclusively pathologic measurement as their reference. To our knowledge, this is the first study exclusively using human
References (18)
- et al.
The pathologic measurement of polyp size is preferable to the endoscopic estimate
Gastrointest Endosc
(1997) - et al.
Automated volumetry at CT colonographya phantom study
Acad Radiol
(2005) - et al.
Computed tomographic virtual colonoscopy to screen for colorectal neoplasia in asymptomatic adults
N Engl J Med
(2003) - et al.
The evolution of cancer of the colon and rectum
Cancer
(1975) CONImmediate colonoscopy is not necessary in patients who have polyps smaller than 1 cm on computed tomographic colonography
Am J Gastroenterol
(2005)- et al.
Risk of invasive carcinoma in colorectal adenomas assessed by size and site
Int J Colorectal Dis
(1997) - et al.
Histological assessment of colorectal adenomas by sizeAre polyps less than 10 mm in size clinically important?
Eur J Surg
(2001) PROpatients with polyps smaller than 1 cm on computed tomographic colonography should be offered colonoscopy and polypectomy
Am J Gastroenterol
(2005)- et al.
CT colonography reporting and data systema consensus proposal
Radiology
(2005)