Original article—alimentary tractRelationship Between Helicobacter pylori Infection and Esophageal Neoplasia: A Meta-analysis
Section snippets
Data Identification and Extraction
We searched the PubMed, MEDLINE, and Embase databases through February 2007 to identify all relevant English language medical literature for human studies under the search text terms helicobacter pylori AND (esophageal cancer OR esophageal neoplasms OR Barrett’s esophagus OR adenocarcinoma OR squamous cell carcinoma). We also performed a full manual search of all review articles, recently published editorials, and retrieved original studies. Data were extracted independently from each study by
Descriptive Assessment and Study Characteristics
A flow chart describing the process of study selection is shown in Figure 1. Of 238 titles initially generated by the literature searches, 18 studies, of which 9 were case-control and 9 cohort studies, remained eligible for meta-analysis.19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36 Initial agreement between the reviewers for the selection of relevant articles was high (κ = 0.94, 95% CI, 0.86–1).
In the 18 meta-analysis studies there were 22 sets of data comparing H
Discussion
In this study we pooled the data of published studies in an effort to examine the relationships between H pylori infection and esophageal neoplasia by meta-analysis of all relevant cohort and case-control studies.
The results showed an inverse relationship of H pylori as well as the H pylori cagA–positive strain prevalence with both BE and AC, suggesting that H pylori infection might play a protective role in this type of esophageal malignancy. The results are in accordance with those of a
Supplementary Data
Note: To access the supplementary material accompanying this article, visit the online version of Clinical Gastroenterology and Hepatology at www.cghjournal.org.
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