Original article—liver, pancreas, and biliary tractAn Assessment of the Severity of Interstitial Pancreatitis
Section snippets
Methods
The demographic, clinical, laboratory, and radiologic data for all patients directly admitted to our institution with a diagnosis of acute pancreatitis between June 2005 and December 2007 were collected prospectively. All patients transferred from outside institutions were excluded from the study. Patients with radiographic evidence of chronic pancreatitis also were excluded from the study. Among patients with prior or multiple episodes of acute pancreatitis, only the first admission for acute
Results
Figure 1 shows the selection criteria of the study cohort. A total of 306 patients with acute pancreatitis were evaluated. We excluded 54 patients transferred from outside institutions. Among these 54 patients, 23 had NP, 25 had IP, and 6 had EXPN. Of the remaining 252 patients who were admitted directly to our institution, we excluded the 17 patients with an unenhanced computed tomography, 11 patients with NP, and 8 patients with EXPN. Among the 216 remaining patients, 115 underwent a CECT (n
Discussion
Our study systematically evaluated severity of IP in a cohort of consecutive nontransferred patients. We found that IP was a very mild disease in nearly all patients with a median length of stay of only 4 days, persistent organ failure in only 1%, and a mortality rate of only 3%.
Mortality in IP was associated significantly with increased comorbidity, persistent SIRS, and persistent organ failure. It appears that comorbidity played a more important role in mortality than the severity of
References (54)
- et al.
Fatal outcome in acute pancreatitis: its occurrence and early prediction
Pancreatology
(2001) - et al.
Computed tomography severity index is a predictor of outcomes for severe pancreatitis
Am J Surg
(2000) - et al.
Update of the Atlanta classification of severity of acute pancreatitis: should a moderate category be included?
Pancreatology
(2010) - et al.
Extrapancreatic necrotizing pancreatitis with viable pancreas: a previously under-appreciated entity
J Am Coll Surg
(1999) - et al.
The effect of age on hospital outcomes in severe acute pancreatitis
Pancreatology
(2008) - et al.
Obesity increases the severity of acute pancreatitis: performance of APACHE-O score and correlation with the inflammatory response
Pancreatology
(2006) - et al.
Obesity is a definitive risk factor of severity and mortality in acute pancreatitis: an updated meta-analysis
Pancreatology
(2006) - et al.
Early changes in blood urea nitrogen predict mortality in acute pancreatitis
Gastroenterology
(2009) - et al.
Simple scoring system for the prediction of the prognosis of severe acute pancreatitis
Surgery
(2007) - et al.
Early systemic inflammatory response syndrome is associated with severe acute pancreatitis
Clin Gastroenterol Hepatol
(2009)
The impact of hospital-acquired infection on outcome in acute pancreatitis
Gastroenterology
A new method of classifying prognostic comorbidity in longitudinal studies: development and validation
J Chron Dis
A new clinical prognostic staging system for acute pancreatitis
Am J Med
Co-morbidity is a strong predictor of early death and multi-organ system failure among patients with acute pancreatitis
J Gastrointest Surg
Admission volume determines outcome for patients with acute pancreatitis
Gastroenterology
Early hemoconcentration predicts increased mortality only among transferred patients with acute pancreatitis
Pancreatology
Acute interstitial pancreatitis; clinical study of thirty seven cases showing oedema, swelling, and induration of pancreas without necrosis, hemorrhage, or suppuration
Surg Gynecol Obstet
Practice guidelines in acute pancreatitis
Am J Gastroenterol
A clinical and morphologic study of forty-two cases of fatal acute pancreatitis
Surg Gynecol Obstet
Acute and subacute interstitial pancreatitis: a clinicopathologic study
Gastroenterology
The diagnostic significance of interstitial pancreatitis found at autopsy
Am J Clin Pathol
Clinical and pathological features of acute interstitial pancreatitis in the aged
Int J Pancreatol
Identification of pancreas necrosis in severe acute pancreatitis: imaging procedures versus clinical staging
Gut
Clinical implications derived from the morphological classification of 89 patients with acute pancreatitis
J Clin Gastroenterol
Organ failure associated with acute pancreatitis in African-American and Hispanic patients
J Natl Med Assoc
Computed tomography versus acute physiology and chronic health evaluation II score in predicting severity of acute pancreatitis: a prospective, comparative study with statistical evaluation
Pancreas
Risk of death from acute pancreatitisRole of early, simple “routine” data
Int J Pancreatol
Cited by (133)
A Systematic Review and Meta-analysis of Opioids vs Nonopioids in Acute Pancreatitis
2022, Gastro Hep AdvancesEarly prediction of severe acute pancreatitis using machine learning
2022, PancreatologyMR Imaging for Early Extrapancreatic Necrosis in Acute Pancreatitis
2021, Academic RadiologyUpdated Review of Radiologic Imaging and Intervention for Acute Pancreatitis and Its Complications
2024, Journal of Intensive Care MedicineCan neutrophil gelatinase-associated lipocalin be a novel and efficient marker to predict the clinical course of acute pancreatitis?
2024, European Review for Medical and Pharmacological Sciences
Conflicts of interest The authors disclose no conflicts.
Funding This study was supported by a research grant from the National Pancreas Foundation (P.A.B. and V.K.S.).