Original articleSystematic reviews and meta-analysesHigh Prevalence of Osteoporosis in Patients With Chronic Pancreatitis: A Systematic Review and Meta-analysis
Section snippets
Criteria for Consideration of Studies
Observational studies that reported data on the prevalence of osteoporosis in patients with chronic pancreatitis were included. The search was not limited by sex, geographic location, or publication status. Studies that were limited solely to pediatric patients (age, <18 y) were excluded. The primary outcome measure of interest was the prevalence of osteoporosis or osteopenia based on bone density measured by dual-energy X-ray absorptiometry (DXA) (T-scores or Z-scores), and, where available,
Search Results
The search and selection process is summarized in Figure 1. Manual searches of the reference sections of relevant articles and reviews did not provide any further articles. Hand-searching through conference proceedings yielded 2 additional studies.
Summary of Studies Included
Eleven studies met the inclusion criteria and were included in the review (Table 1).2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15 Of these, 8 were full articles and 3 were abstracts of conference proceedings. Of the 11 studies, 8 were conducted in Europe, 2
Discussion
In this systematic review on the prevalence of osteoporosis and osteopenia in chronic pancreatitis, 11 studies were reviewed.2, 3, 4, 5, 9, 10, 11, 12, 13, 14, 15 We showed a high prevalence of osteoporosis in chronic pancreatitis, and also a high prevalence of overall osteopathy. By using the available data, we calculated that the prevalence of osteoporosis in chronic pancreatitis may be as high as 1 patient in 4. Similarly, by calculating a pooled prevalence, as many as two thirds of chronic
Acknowledgments
The authors wish to acknowledge Tim Grant and Ricardo Segurado (Medical Statisticians from the Centre for Support and Training in Analysis and Research, University College Dublin) for statistical assistance and advice. The authors also wish to acknowledge contributions to discussions by members of The Centre for Pancreatic-Biliary Disease, and the Department of Clinical Nutrition & Dietetics, Tallaght Hospital, Dublin, Ireland. The authors are grateful to the following researchers for providing
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Conflicts of interest The authors disclose no conflicts.
Funding This study was supported by an unrestricted grant from the Health Research Board, Ireland, by means of a Health Professional's Fellowship (HPF 2009/046 to S.N.D.).