Original articleClinical endoscopyUse of antimicrobials for EUS-guided FNA of pancreatic cysts: a retrospective, comparative analysis
Section snippets
Data collection
A retrospective review of all patients who underwent EUS-FNA at the Hospital of the University of Pennsylvania from May 2007 to April 2010 was performed. Standardized data collection sheets were used to extract relevant data from the previous visits at doctors' offices and from endoscopy, radiology, and pathology reports. Patient demographic and clinical data, lesion characteristics, and procedure data were documented. For the analysis of the use of antibiotics before, during, or after the
General description
A total of 317 EUS procedures were performed to evaluate pancreatic cystic lesions. FNA was not performed in 51 cases, based on the size or location of the lesion, the indication, or patient intolerance to the procedure. EUS-FNA was completed in 266 endoscopies on 253 patients (13 patients had repeat EUS-FNA studies between 1 and 3 years after the initial study). Of the procedures included in the study, 97% were performed on an outpatient basis. Fifty-nine percent (157) were performed with
Discussion
Safety of EUS-FNA in solid pancreatic lesions has been demonstrated in previous studies reporting a low incidence of bacteremia.3, 4, 5, 6 Because patients presented no overt symptoms of infection, the use of FNA in solid pancreatic lesions is considered a low-risk procedure for infection and does not warrant prophylaxis. Early in its development, however, a prospective series of 18 patients undergoing EUS-FNA of cystic lesions reported two cases of fever after FNA of pancreatic cysts.7 One
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DISCLOSURE: C. Guarner-Argente received financial support from the Instituto de Salud Carlos III, Government of Spain (BAE grant 2010: BA10-00011) and from the Societat Catalana de Digestologia. No other financial relationships relevant to this publication were disclosed.