Elsevier

Microbes and Infection

Volume 17, Issue 3, March 2015, Pages 173-183
Microbes and Infection

Review
How bacterial pathogens colonize their hosts and invade deeper tissues

https://doi.org/10.1016/j.micinf.2015.01.004Get rights and content
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open access

Abstract

Bacterial pathogens have evolved a wide range of strategies to colonize and invade human organs, despite the presence of multiple host defense mechanisms. In this review, we will describe how pathogenic bacteria can adhere and multiply at the surface of host cells, how some bacteria can enter and proliferate inside these cells, and finally how pathogens may cross epithelial or endothelial host barriers and get access to internal tissues, leading to severe diseases in humans.

Keywords

Bacterial invasion
Bacterial adhesion
Microbiota
Host barrier
Host–pathogen interactions
Listeria

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