MALT lymphomaFavorable outcomes of radiotherapy for early-stage mucosa-associated lymphoid tissue lymphoma
Section snippets
Patient characteristics
Patients with early-stage MALT lymphoma treated with RT from 1988 to May 2008 at Aichi Cancer Center Hospital were reviewed. Patients with transformed MALT lymphoma or primary nodal marginal zone B-cell lymphoma, MALT type, were excluded. The pathologic diagnoses were based on the examination of the hematoxylin and eosin-stained biopsy specimens and supported by immunohistochemical analysis. Immunologic phenotyping with paraffin sections was performed for κ and λ light chain restriction, CD20+,
Response and survival
At the time of evaluation, 49 of 50 patients had achieved CR, which resulted in a 98% CR rate (95% confidence interval [CI], 93.9–100%). The remaining one patient, who had conjunctiva MALT lymphoma, achieved partial response (PR) 6 months after RT; however, this patient has shown no recurrence during a follow-up period of 92 months. Although no patients had disease recurrence in the RT field, seven patients had experienced recurrence outside the RT field. Thus, the 5-year LC rate was 100%. The
Discussion
This study reports on the treatment outcomes of patients with early-stage MALT lymphoma treated with RT. Most patients underwent RT alone as a component of their initial therapy except for H. pylori eradication therapy for gastric MALT lymphoma. The most common sites of involvement were the stomach, orbit, conjunctiva/eyelid, and parotid gland. In this study RT was highly effective and achieved a CR rate of 98% and a 5-year local control rate of 100% in cases of early-stage MALT lymphoma. These
References (31)
- et al.
Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. MALT lymphoma study group
Lancet
(1995) - et al.
Clinical activity of rituximab in extranodal marginal zone B-cell lymphoma of MALT type
Blood
(2003) - et al.
Large cohort dose-volume response analysis of parotid gland function after radiotherapy: intensity-modulated VERSUS conventional radiotherapy
Int J Radiat Oncol Biol Phys
(2008) - et al.
Interleukin-11: review of molecular, cell biology, and clinical use
Blood
(1997) - et al.
A revised European--American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group
Blood
(1994) - et al.
Treatment results of radiotherapy for malignant lymphoma of the orbit and histopathologic review according to the WHO classification
Int J Radiat Oncol Biol Phys
(2003) - et al.
A multicenter phase II study of local radiation therapy for stage IEA mucosa-associated lymphoid tissue lymphomas: a preliminary report from the Japan Radiation Oncology Group (JAROG)
Int J Radiat Oncol Biol Phys
(2007) - et al.
Primary radiotherapy for localized orbital MALT lymphoma
Int J Radiat Oncol Biol Phys
(2002) - et al.
Mucosa-associated lymphoid tissue lymphoma with initial supradiaphragmatic presentation: natural history and patterns of disease progression
Int J Radiat Oncol Biol Phys
(2000) - et al.
Efficacy and treatment-related toxicity of radiotherapy for early-stage primary non-Hodgkin lymphoma of the parotid gland
Int J Radiat Oncol Biol Phys
(2004)
Orbital lymphoma: is it necessary to treat the entire orbit?
Int J Radiat Oncol Biol Phys
Orbital lymphoma: radiotherapy outcome and complications
Radiother Oncol
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue arising in the extracranial head and neck region: a high rate of dissemination and disease recurrence
Oral Oncol
Orbital marginal zone B-cell lymphoma of MALT: radiotherapy results and clinical behavior
Int J Radiat Oncol Biol Phys
Mucosa-associated lymphoid tissue lymphoma is a disseminated disease in one third of 158 patients analyzed
Blood
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