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Overexpression of Platelet-Derived Growth Factor (PDGF) B Chain and Type β PDGF Receptor in Human Chronic Pancreatitis

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Abstract

Platelet-derived growth factors (PDGF) aremitogenic polypeptides that are involved in cellularproliferation and tissue repair. The expression of PDGFsand type β PDGF receptor was examined in the normal human pancreas and in chronic pancreatitis, afibrotic disease associated with fibroblasticproliferation, atrophy, and acinar celldedifferentiation. In the normal human pancreas, PDGF Achain mRNA levels were relatively abundant, whereas PDGF B chainmRNA levels were not detected, and type β PDGFreceptor mRNA transcripts were present at low levels. Inthe normal pancreas, PDGF immunoreactivity was present in islet cells, whereas type β PDGFreceptor immunoreactivity was present in acinar cells.In chronic pancreatitis, PDGF A chain mRNA transcriptswere also abundant, and 11 of 19 samples exhibited the PDGF B chain mRNA transcript. In addition,there was a significant increase in the mRNA levels oftype β PDGF receptor in the pancreatitis samples bycomparison with the normal pancreas (P < 0.001). In chronic pancreatitis tissues, PDGF and typeβ PDGF receptor immunoreactivity were present inacinar, ductal, islet, and endothelial cells,fibroblasts, and leukocytes. The concomitantoverexpression of PDGFs and of the type β PDGF receptorpoints to the existence of autocrine and paracrinePDGFdependent loops in human chronicpancreatitis.

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Authors
  1. Matthias Ebert
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  2. Hans-Udo Kasper
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  3. Sara Hernberg
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  4. Helmut Friess
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  5. Markus W. Buchler
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  6. Albert Roessner
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  7. Murray Korc
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  8. Peter Malfertheiner
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Ebert, M., Kasper, HU., Hernberg, S. et al. Overexpression of Platelet-Derived Growth Factor (PDGF) B Chain and Type β PDGF Receptor in Human Chronic Pancreatitis. Dig Dis Sci 43, 567–574 (1998). https://doi.org/10.1023/A:1018867209170

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