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Crohn's Disease Stable Remission After Human Immunodeficiency Virus Infection

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Abstract

We retrospectively assessed the clinical coursein four patients with long-standing Crohn's disease whobecame infected with human immunodeficiency virus (HIV).The duration of active Crohn's disease was 21, 10, 4, and 4 years in our four patients.They experienced a stable remission of Crohn's diseasesymptoms after HIV infection. In three patients Crohn'sdisease was in stable remission for 5, 8, and 8 years after HIV infection and all three diedfrom acquired immunodeficiency syndrome-related disease.One patient was still alive without recurrence ofCrohn's disease symptoms 7 years following HIVdetection. Our observations of a spontaneous improvementin the clinical course of Crohn's disease after HIVinfection, suggests that the integrity of the immuneresponse, especially that of CD4 T cells, plays a major role in the tissue injury mechanism in Crohn'sdisease.

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Authors
  1. D. Pospai
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  2. E. Rene
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  3. R. Fiasse
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  4. K. Farahat
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  5. L. Beaugery
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  6. P. Lammens
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  7. C. Reimund
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  8. B. Duclos
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  9. Y. Le Quintrec
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  10. B. Vandercam
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  11. M. Mignon
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Pospai, D., Rene, E., Fiasse, R. et al. Crohn's Disease Stable Remission After Human Immunodeficiency Virus Infection. Dig Dis Sci 43, 412–419 (1998). https://doi.org/10.1023/A:1018883112012

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