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Serological Markers and HLA-DQ2 Haplotype Among First-Degree Relatives of Celiac Patients

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Abstract

Serologic markers, HLA-DQ2 haplotype, andclinical features suggestive of celiac disease werestudied to assess their diagnostic value in amulticentric study to detect celiac disease in 675first-degree relatives of 227 celiac probands. SerumIgA-class anti-endomysium and IgA-class anti-gliadinantibodies were positive in 5.8% and 1.9% of relatives,respectively. HLA-DQ2 haplotype was present in 64% of relatives, and the overall rate of celiacdisease diagnosed by intestinal biopsy was 5.5% . Thefrequency of HLA-DQ2 in the celiac patients and controlswas 93% and 18% , respectively. The most frequent clinical features — diarrhea, anemia,food intolerance, and growth retardation — werenot present in one third of the celiac diseaserelatives. We conclude that the assessment of IgA-classanti-endomysium antibodies alone seems a reasonable approachfor screening celiac disease in relatives and cannot bereplaced by an accurate clinical anamnesis. HLA-DQ2haplotype may identify the population with a high genetic susceptibility to celiacdisease.

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Authors
  1. Carme Farre
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  2. Pere Humbert
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  3. Pere Vilar
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  4. Vicente Varea
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  5. Xavier Aldeguer
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  6. Jesus Carnicer
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  7. Miguel Carballo
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  8. Miquel Angel Gassull
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Farre, C., Humbert, P., Vilar, P. et al. Serological Markers and HLA-DQ2 Haplotype Among First-Degree Relatives of Celiac Patients. Dig Dis Sci 44, 2344–2349 (1999). https://doi.org/10.1023/A:1026685527228

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