Abstract
Transgenic mouse studies designed to explore T cell-mediated immunity in the gut (page 900) uncover another function for COX-2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Newberry, R.D., Stenson W.F. & Lorenz, R.G. Cyclooxygenase-2 dependent arachidonic acid metabolites are critical modulators of the intestinal immune response to dietary antigen. Nature Med. 5, 900–906 (1999).
Strober, W., Kelsall, B. & Marth,T. Oral Tolerance. J. Clin Immunol. 18, 1–30 (1998).
Rath, H.C. et al. Normal luminal bacteria, especially Bacteroides species, mediate chronic colitis, gastritis, and arthritis in HLA-B27/human beta2 microglobulin transgenic rats. J. Clin Invest, 15, 945 –953 (1996).
Dianda L. et al. T cell receptor-alpha beta-deficient mice fail to develop colitis in the absence of a microbial environment. Am. J. Pathol. 150, 91–97 (1997).
Contractor, N.V. et al. Lymphoid hyperplasia, autoimmunity, and compromised intestinal intraepithelial lymphocyte development in colitis-free gnotobiotic IL-2-deficient mice. J. Immunol. 160, 385– 394 (1998).
Sellon, R.K. et al. Resident enteric bacteria are necessary for development of spontaneous colitis and immune system activation in interleukin-10-deficient mice. Infect. Immun. 66, 5224– 5231 (1998).
Masferrer, J.L. et al. Selective inhibition of inducible cyclooxygenase. Proc. Natl. Acad. Sci. USA 91, 3228– 3232 (1994).
Seibert, K. et al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA 91, 12013–12017 (1994).
Gilroy, D.W. et al. Inducible cyclooxygenase may anti-inflammatory properties. Nature Med. 5, 698–701 (1999).
Mizuno, H. et al. Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice. Gastroenterology 112, 645–648 (1997).
Reuter, B.K., Asfaha, S., Buret, A., Sharkey, K.A. & Wallace, J.L. Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2. J. Clin. Invest. 98, 2076–2085 ( 1996).
Morteau, O., Morham, S., Sellon, S., Smithies, O. & Sartor, R.B. Genetic deficiency in cyclooxygenase-2 but not in cyclooxygenase-1 exacerbates DSS-induced acute colitis in mice. Gastroenterology 112, A1046 ( 1997).
Flannigan, A. et el. Pharmacologic inhibition and cyclooxygenase (COX)-2 gene knockout intensifies dextran sulfate (DSS)-induced colitis in mice. Gastroenterology 116, A880 (1999).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Morteau, O. COX-2: promoting tolerance. Nat Med 5, 867–868 (1999). https://doi.org/10.1038/11301
Issue Date:
DOI: https://doi.org/10.1038/11301
This article is cited by
-
Cyclooxygenase-2 in mucosal DC mediates induction of regulatory T cells in the intestine through suppression of IL-4
Mucosal Immunology (2009)
-
Nuclear factor κB is activated in small intestinal mucosa of celiac patients
Journal of Molecular Medicine (2003)