Abstract
Idiopathic inflammatory bowel disease is a chronic relapsing condition. The role of stress in causing relapses of inflammatory bowel disease remains controversial. We now show that colitis induced in mice by dinitrobenzenesulfonic acid (DNBS) resolves by 6 weeks, but can subsequently be reactivated by stress plus a sub-threshold dose of DNBS, but not by DNBS alone. Stress reduced colonic mucin and increased colon permeability. Susceptibility to reactivation by stress required CD4+ lymphocytes and could be adoptively transferred. We conclude that stress reactivates experimental colitis by facilitating entry of luminal contents that activate previously sensitized CD4 cells in the colon.
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Acknowledgements
This study was supported by grants to SMC from the Medical Research Council of Canada, and from a Research Initiative Award from the Canadian Association of Gastroenterology and Astra Canada.
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Qiu, B., Vallance, B., Blennerhassett, P. et al. The role of CD4+ lymphocytes in the susceptibility of mice to stress-induced reactivation of experimental colitis. Nat Med 5, 1178–1182 (1999). https://doi.org/10.1038/13503
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DOI: https://doi.org/10.1038/13503
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