Abstract
Colonization of the human stomach by the bacterium Helicobacter pylori is a predisposing factor for gastrointestinal illnesses such as gastritis and peptic ulcers1. But most infections are asymptomatic, and it has recently been suggested that H. pylori may actually have beneficial effects on infected carriers who are heavily exposed to other gastrointestinal pathogens2. We find that H. pylori possesses antibacterial activity to which it is itself resistant. We have traced this activity to cecropin-like amino-terminal peptides derived from the ribosomal protein L1 (RpL1).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Blaser, M. Br. Med. J. 316, 1507–1510 (1998).
Mattson, A., Lönroth, H., Qiuding-Järbrink, M. & Svennerholm, A.-M. J. Clin. Invest. 102, 51–56 (1998).
Hultmark, D. et al. EMBO J. 2, 571–576 (1983).
Boman, H. G. Scand. J. Immunol. 48, 15–25 (1998).
Sahl, H. G. & Bierbaum, G. Annu. Rev. Microbiol. 52, 41–79 (1998).
Holak, T. A. et al. Biochemistry 27, 7620–7629 (1988).
DeLucca, A. J., Jacks, T. J. & Brogden, K. A. Mol. Cell Biochem. 151, 141–148 (1995).
Suda, Y. et al. J. Biochem. 121, 1129–1133 (1997).
Phadnis, S. H. et al. Infect. Immun. 64, 905–912 (1995).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pütsep, K., Brändén, CI., Boman, H. et al. Antibacterial peptide from H. pylori. Nature 398, 671–672 (1999). https://doi.org/10.1038/19439
Issue Date:
DOI: https://doi.org/10.1038/19439
This article is cited by
-
Simultaneous Production of Antibacterial Protein and Lipopeptides in Bacillus tequilensis, Detected by MALDI-TOF and GC Mass Analyses
Probiotics and Antimicrobial Proteins (2023)
-
Novel antimicrobial activity of protein produced by Streptomyces lividans TK24 against the phytopathogen Clavibacter michiganensis
Archives of Microbiology (2022)
-
The number of household members as a risk factor for peptic ulcer disease
Scientific Reports (2021)
-
Peptides with Dual Antimicrobial-Anticancer Activity Derived from the N-terminal Region of H. pylori Ribosomal Protein L1 (RpL1)
International Journal of Peptide Research and Therapeutics (2021)
-
Anticancer activity of Helicobacter pylori ribosomal protein (HPRP) with iRGD in treatment of colon cancer
Journal of Cancer Research and Clinical Oncology (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.