Abstract
Adams and Cobb1 directed attention to the fact that certain non-hormonal antirheumatic (anti-inflammatory) drugs uncouple oxidative phosphoryl-ation in liver mitochondria, citing phenylbutazone and salicylic acid as two examples. This correlation can now be extended to include certain analogues of these two drugs and at least three other types of anti-inflammatory agents not chemically related to either salicylate or phenylbutazone, exemplified by cincho-phene, glycyrrhetinic acid and certain derivatives of anthranilic acid.
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WHITEHOUSE, M., HASLAM, J. Ability of Some Antirheumatic Drugs to uncouple Oxidative Phosphorylation. Nature 196, 1323–1324 (1962). https://doi.org/10.1038/1961323a0
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DOI: https://doi.org/10.1038/1961323a0
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